Arbeitsgemeinschaft
für angewandte
Humanpharmakologie e.V

Association for
Applied Human
Pharmacology

  

> The AGAH > Publications 

Review on Biomarkers for THC and Cannabis Effects

The AGAH Biomarker working group has published a review on Biomarkers for the effects of cannabis and THC in healthy volunteers in the British Journal of Clinical Pharmacology.

Declaration of Helsinki as of October 2008

pdf
Declaration_of_Helsinki_2008.pdf 

Reviews on Biomarkers in Phase I

The working group of the regents' project "biomarkers" has published several reviews on "biomarkers in phase I".

  • Dumont GJ, de Visser SJ, Cohen AF, van Gerven JM
    Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects
    Br J Clin Pharmacol. 2005;59:495-510
  • de Visser SJ, van der Post JP, de Waal PP, Cornet F, Cohen AF, van Gerven JM
    Biomarkers for the effects of benzodiazepines in healthy volunteers
    Br J Clin Pharmacol. 2003; 55:39-50
  • Rijnbeek B, de Visser SJ, Franson KL, Cohen AF, van Gerven JM
    REM sleep effects as a biomarker for the effects of antidepressants in healthy volunteers
    J Psychopharmacol. 2003; 17:196-203

Compendium Clinical Pharmacology (German)

Editors: C. Herrlinger and W. Cawello

Authors: A. Bastek, K. Breithaupt-Grögler, W. Cawello, B. Dietrich, K. M. Eckl, S. Hantel, M. Hartman, C. Herrlinger, K. Herz, B. Hughes-Formella, K.-D. Keller, U. Klotz, C. Meyerhoff, M. Mörike, B. Mühlbauer, J.H. Nagelschmitz, U. Paschen, J. Schwarz, P. Sefrin, H. W. Seyberth, M. und W. Söhngen, T. Sudhop, W. Timmer, T. Thomson, K. von Bergmann, T. Zilker and M. Zühlsdorf

Publisher: Shaker Aachen, 2002, ISBN 3-8265-9864-4

 

The compendium is a compact training textbook in preparation for the board certification exam in "Clinical Pharmacology" and is based on the curricula of the federal medical associations.

The textbook can be ordered via book shops or the publisher. 

Collection of terms, symbols, equations, and explanations of common pharmacokinetic and pharmacodynamic parameters and some statistical functions

Publisher: The pharmacokinetics working group of the AGAH

pdf
PK-glossary_PK_working_group_2004.pdf 

Parameters for Compartment-free Pharmacokinetics

Standardisation of Study Designs, Data Analysis and Reporting (Englisch)

Editor: W. Cawello

Authors: A. Baumann, M. A. Brett, W. Cawello, R. Gieschke, G. Pabst, B. Sierakowski, H-J. Weimann, and H. Zimmermann

Publisher: Shaker Aachen, 1999, ISBN 3-8265-4767-5

Table of contents:

  • Pharmacokinetic symbols, nomenclature
  • The physiological basis of pharmacokinetics
  • Drug concentrations and directly derived parameters
  • Half-life
  • The area under the concentration-time curve
  • Clearance
  • Mean-time parameters
  • Presenting and reporting pharmacokinetic data
  • Bioavailability and bioequivalence
  • Study designs tailor-made for different pharmacokinetic trials
  • Glossary

The book can be ordered from your local book shop or the publisher.

Parameter zur modellunabhängigen Pharmakokinetik (Parameters for Compartment-free Pharmacokinetics)

Standardisierung von Planung, Auswertung und Berichterstattung (German language)

Editor: W. Cawello

Autors: A. Baumann, M. A. Brett, W. Cawello, R. Gieschke, G. Pabst, B. Sierakowski, H-J. Weimann, and H. Zimmermann

Publisher: Shaker Aachen, 1998, ISBN 3-8265-3940-0

Table of content:

  • Pharmakokinetische Symbole, Nomenklatur
  • Physiologische Basis der Pharmakokinetik
  • Konzentrationen und daraus direkt abgeleitete Parameter
  • Halbwertszeit
  • Fläche unter der Konzentrations-Zeit-Kurve
  • Clearance
  • Mean-time Parameter
  • Darstellung pharmakokinetischer Daten und Ergebnisse
  • Bioverfügbarkeit und Bioequivalenz
  • Optimales Design für Studien unterschiedlicher Fragestellung
  • Studien an speziellen Populationen
  • Glossar
  • Literatur
  • Stichwortverzeichnis

Das Buch kann über den Buchhandel oder direkt beim Verlag bezogen werden.

 

6th Annual Meeting of the AGAH: PK/PD Modelling

Editors: Dehrendorf, Hecht, Plettenberg, Rosenthal

International Journal of Clinical Pharmacology and Therapeutics Vol. 35, No. 10, 1997

 

Pharmacodynamic Methods: Inventory and Critical Appraisal

Editors: Gleiter, Hecht, Derendorf

The Journal of Clinical Pharmacology Vol. 37, No. 1, Supplement, 1997

Table of contents:

  • Introduction
  • The Role of Pharmacodynamics in Drug Research and Therapeutics
  • Optimization of Methods and Models in Clinical Pharmacology
  • Generation of Field Potentials in the Brain
  • Usefulness, Usability, and Quality Criteria for Noninvasive Methods in Cardiovascular Clinical Pharmacology
  • Continuous Measurement of Hemodynamic Alterations During Pharmacologic Cardiovascular Stress Using Automated lmpedance Cardiography
  • Methods for Assessing the Effects of Drugs on Gastrointestinal Function in Patients and Healthy Volunteers
  • 24-Hour Recording of Intragastric pH in Clinical Trials: Preconditions, Methodology, and Standardization Strategies
  • Use of Probe Drugs as Predictors of Drug Metabolism in Humans
  • Pharmacodynamic Models to Evaluate Antithrombotics in Clinical Pharmacology
  • Inhibition of Platelet Aggregation as a Surrogate Marker
  • The Correlation Between Pharmacodynamics and Pharmacokinetics: Basics of Pharmacokinetics-Pharmacodynamics Modeling
  • Polysomnography in Drug Development
  • Noninvasive Method for Measuring Thrombus Formation in Patients after Peripheral Angioplasty Using Three-Dimensional B-Mode and Color-Coded Doppler Ultrasonography

Erstanwendung am Menschen (First in Man Trials)

Editor: C. H. Gleiter

AGAH, 1997, ISBN 3-932561-00-7 (German language)

 

Klinische Arzneimittelprüfungen an Frauen

Überlegungen zum Thema Schwangerschaftsverhütung

Authors: K. Breithaupt-Grögler, D. Heger-Mahn, C. Klipping, R. Butzer, I. Duijkers, D. Geyer, R. Hermann, C. Hinze, M. Mahler, M. Seibert-Grafe, and K. Westermann

Deutsches Ärzteblatt 1997, 94, Heft 15, A991-993 (German language)

 

Ethikkommissionen in der Arzneimittelforschung

Wachsende Bedeutung internationaler Regeln

C. H. Gleiter (German language)

Deutsches Ärzteblatt 94, Ausgabe 8 vom 21.02.1997, Seite A-439 / B-388 / C-350

Page updated: 23-06-2009